Description

2-Bromo-4-(Difluoromethoxy)-1-Nitrobenzene is a high-value, multi-functional aromatic intermediate featuring bromo, difluoromethoxy, and nitro substituents. This compound is critical for the synthesis of advanced agrochemicals and pharmaceuticals, where its unique halogenated and fluorinated structure imparts desirable biological activity and metabolic stability. It is primarily sought after by R&D chemists and process development scientists in the fine chemical, agrochemical, and pharmaceutical industries for constructing complex molecular architectures.

Application

• Agrochemical Intermediate: A key building block for the synthesis of novel herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the difluoromethoxy and bromo groups.
• Pharmaceutical Intermediate: Used in the research and development of active pharmaceutical ingredients (APIs), particularly in the creation of molecules targeting central nervous system (CNS) disorders and inflammatory diseases.
• Ligand and Catalyst Synthesis: Serves as a precursor for specialized ligands in catalysis and materials science due to its electron-withdrawing nitro group and halogen atom.
• Fluorinated Compound Research: An essential reagent in medicinal chemistry for studying structure-activity relationships (SAR) and improving drug-like properties such as lipophilicity and membrane permeability.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific, high-purity halogenated nitrobenzene derivatives.

Basic Information

Product Name	2-Bromo-4-(Difluoromethoxy)-1-Nitrobenzene
CAS No.	865886-83-5
Molecular Formula	C7H4BrF2NO3
Molecular Weight	267.01 g/mol
Synonyms	1-Bromo-2-(difluoromethoxy)-5-nitrobenzene; 2-Bromo-1-nitro-4-(difluoromethoxy)benzene; Benzene, 2-bromo-1-nitro-4-(difluoromethoxy)-; 865886-83-5; 2-Bromo-4-difluoromethoxy-1-nitrobenzene; 4-Bromo-3-(difluoromethoxy)nitrobenzene; 5-Bromo-2-(difluoromethoxy)nitrobenzene
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-4-(Difluoromethoxy)-1-Nitrobenzene is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment to guarantee traceability and batch-to-batch consistency for your R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible materials such as strong bases and reducing agents. The compound is light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.