Description

2-Morpholino-5-(Trifluoromethyl)Benzoic Acid is a high-value, multifunctional benzoic acid derivative featuring a morpholine ring and a trifluoromethyl group, making it a versatile building block for advanced chemical synthesis. This compound is particularly significant for its role in pharmaceutical research and development, where its unique structure is leveraged to modulate the physicochemical properties of active molecules. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and antiviral therapeutic areas.
• Agrochemical Synthesis: Used as a precursor in the design of modern herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a functionalized backbone for creating novel ligands used in catalytic processes and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of advanced polymers and organic electronic materials due to its electron-withdrawing and donating moieties.
• Chemical Biology Probe: Utilized as a building block for developing molecular probes to study biological pathways and enzyme functions.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes under cGMP or ISO standards.

Basic Information

Product Name	2-Morpholino-5-(Trifluoromethyl)Benzoic Acid
CAS No.	865471-20-1
Molecular Formula	C₁₂H₁₂F₃NO₃
Molecular Weight	275.23 g/mol
Synonyms	5-(Trifluoromethyl)-2-morpholinobenzoic Acid; 2-Morpholin-4-yl-5-(trifluoromethyl)benzoic Acid; Benzoic acid, 2-morpholino-5-(trifluoromethyl)-; 865471-20-1; 2-(Morpholin-4-yl)-5-(trifluoromethyl)benzoic acid; 4-[4-(Trifluoromethyl)-2-carboxyphenyl]morpholine
EINECS	Contact for details

Quality Control

Our 2-Morpholino-5-(Trifluoromethyl)Benzoic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.