Description

(3-((4-(tert-Butoxycarbonyl)Piperazin-1-Yl)Methyl)Phenyl)Boronic Acid is a sophisticated boronic acid derivative featuring a protected piperazine moiety, serving as a critical building block in modern synthetic chemistry. Its primary value lies in its dual functionality, enabling efficient cross-coupling reactions while offering a protected amine handle for further orthogonal derivatization. This compound is essential for researchers and manufacturers in pharmaceutical development, particularly in the synthesis of complex small molecule APIs and targeted drug candidates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates, especially those targeting neurological disorders and oncology.
• Suzuki-Miyaura Cross-Coupling: Utilized as a versatile boronic acid coupling partner for constructing biaryl and heterobiaryl scaffolds central to medicinal chemistry.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a linker component connecting E3 ligase ligands to target protein binders.
• Peptidomimetic & Macrocycle Synthesis: Enables the incorporation of rigid, functionalized aromatic systems into complex peptide-like structures.
• Material Science Research: Used in creating novel organic frameworks and polymers with specific electronic or structural properties.
• Chemical Biology Probe Development: Acts as a handle for bioconjugation and labeling strategies in target identification studies.

Basic Information

Product Name	(3-((4-(tert-Butoxycarbonyl)Piperazin-1-Yl)Methyl)Phenyl)Boronic Acid
CAS No.	865314-28-9
Molecular Formula	C17H27BN2O4
Molecular Weight	334.22 g/mol
Synonyms	[3-[[4-[(1,1-Dimethylethoxy)carbonyl]-1-piperazinyl]methyl]phenyl]boronic Acid; (3-((4-(Boc)Piperazin-1-yl)Methyl)Phenyl)Boronic Acid; Boc-Pip-Me-Ph-B(OH)2; 3-((4-(tert-Butoxycarbonyl)Piperazin-1-yl)Methyl)Benzeneboronic Acid; 1-Boc-4-[(3-Boronobenzyl)]Piperazine; N-Boc-4-(3-Boronobenzyl)Piperazine; tert-Butyl 4-((3-boronobenzyl))piperazine-1-carboxylate
EINECS	Contact for details

Quality Control

Every batch of (3-((4-(tert-Butoxycarbonyl)Piperazin-1-Yl)Methyl)Phenyl)Boronic Acid is manufactured under strict quality management systems. Our products undergo rigorous quality testing to ensure compliance with industry standards for pharmaceutical intermediates. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Allow the sealed container to reach ambient temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.