Description

8-Quinolinamine, 5,6,7,8-Tetrahydro-, Hydrochloride (1:2), (8S)- is a high-purity, stereochemically defined chemical intermediate of significant interest in advanced organic synthesis. Its value lies in its role as a key chiral building block for the development of complex molecules, particularly in the pharmaceutical sector. This compound is essential for researchers and manufacturers in medicinal chemistry, process development, and fine chemical production who require reliable access to high-quality, structurally specific intermediates.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting the central nervous system.
• Medicinal Chemistry Research: Used as a scaffold or building block in drug discovery programs for the development of new therapeutic agents.
• Asymmetric Synthesis: Employed in catalytic and stoichiometric asymmetric reactions to introduce the tetrahydroquinoline core with defined stereochemistry.
• Fine Chemical Production: Integral to the multi-step synthesis of specialty chemicals, agrochemicals, and advanced materials requiring high structural fidelity.
• Reference Standard: Can be utilized as an analytical standard for quality control and method development in regulatory and R&D laboratories.

Basic Information

Product Name	8-Quinolinamine, 5,6,7,8-Tetrahydro-, Hydrochloride (1:2), (8S)-
CAS No.	865303-57-7
Molecular Formula	C9H14N2 · 2HCl
Molecular Weight	239.15 g/mol
Synonyms	(8S)-5,6,7,8-Tetrahydroquinolin-8-amine dihydrochloride; (8S)-5,6,7,8-Tetrahydro-8-quinolinamine dihydrochloride; (S)-5,6,7,8-Tetrahydroquinolin-8-amine dihydrochloride; (S)-8-Amino-5,6,7,8-tetrahydroquinoline dihydrochloride; (S)-Tetrahydroquinolin-8-amine dihydrochloride; (8S)-THQ-amine 2HCl; Chiral Tetrahydroquinoline Amine Dihydrochloride
EINECS	Contact for details

Quality Control

Our (8S)-5,6,7,8-Tetrahydroquinolin-8-amine dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) providing batch-specific data for identity, purity, and chiral excess is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.