Description

(3S)-3-(4-Hydroxyphenyl)-4-Hexynoic Acid CAS NO 865233-35-8 is a chiral, non-natural amino acid derivative featuring a phenolic hydroxyl group and an alkyne moiety, making it a versatile and valuable synthetic building block. This compound is specifically designed for advanced pharmaceutical research and fine chemical synthesis, where precise stereochemistry and functional group compatibility are critical. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and metabolic disease research.
• Peptidomimetics & Bioconjugation: The alkyne group enables click chemistry reactions (e.g., CuAAC) for labeling, probe development, and creating peptide analogs with enhanced stability.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands used in asymmetric catalysis, improving enantioselectivity in industrial chemical processes.
• Material Science Research: Used in the development of functional polymers and advanced materials where the phenolic and carboxylic acid groups offer sites for modification and cross-linking.
• Agrochemical Synthesis: Employed in the research and development of new herbicides and plant growth regulators with specific chiral activity.

Basic Information

Product Name	(3S)-3-(4-Hydroxyphenyl)-4-Hexynoic Acid
CAS No.	865233-35-8
Molecular Formula	C12H12O3
Molecular Weight	204.22 g/mol
Synonyms	(S)-3-(4-Hydroxyphenyl)-4-hexynoic acid; (3S)-3-(4-Hydroxyphenyl)hex-4-ynoic acid; 4-Hexynoic acid, 3-(4-hydroxyphenyl)-, (3S)-; (S)-3-(p-Hydroxyphenyl)-4-hexynoic acid; (S)-HPA; (3S)-HPA; (S)-3-(4-Hydroxyphenyl)hex-4-ynoate
EINECS	Contact for details

Quality Control

Our (3S)-3-(4-Hydroxyphenyl)-4-Hexynoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure high chemical and optical purity suitable for research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.