Description

(2R)-2-Amino-3,3-Dimethyl-Butan-1-Ol Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant commercial importance. This compound is valued for its role in the synthesis of complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily needed by research institutions, pharmaceutical manufacturers, and fine chemical producers engaged in asymmetric synthesis and drug discovery programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel APIs, especially for antiviral, anticancer, and neurological drugs.
• Asymmetric Synthesis: Used as a chiral auxiliary or precursor in stereoselective chemical reactions to introduce the tert-leucinol moiety.
• Peptidomimetics & PROTACs: Serves as a building block for constructing peptide analogs and Proteolysis Targeting Chimeras (PROTACs) due to its rigid, bulky side chain.
• Catalyst & Ligand Preparation: Employed in the development of chiral catalysts and ligands for homogeneous catalysis.
• Bioconjugation & Linker Chemistry: Utilized in the design of chemical linkers for antibody-drug conjugates (ADCs) and other bioconjugation applications.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and medicinal chemistry research.

Basic Information

Product Name	(2R)-2-Amino-3,3-Dimethyl-Butan-1-Ol Hydrochloride
CAS No.	864820-00-8
Molecular Formula	C6H16ClNO
Molecular Weight	153.65 g/mol
Synonyms	(R)-2-Amino-3,3-dimethylbutan-1-ol hydrochloride; (R)-tert-Leucinol hydrochloride; (2R)-2-Amino-3,3-dimethyl-1-butanol hydrochloride; (R)-2-Amino-3,3-dimethylbutanol HCl; (R)-Amino-tert-butyl-ethanol hydrochloride; (R)-1-Amino-2-hydroxy-3,3-dimethylbutane hydrochloride; (R)-H2N-tertLeu-ol HCl
EINECS	Contact for details

Quality Control

Our (2R)-2-Amino-3,3-Dimethyl-Butan-1-Ol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with high-purity standards suitable for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.