Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-7-(4-Nitroso-1-Piperazinyl)-4-Oxo- is a sophisticated, high-purity pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is of critical importance for its role as a key building block in the synthesis of advanced active pharmaceutical ingredients (APIs), particularly within the fluoroquinolone antibiotic class. It is essential for research and development chemists, process scale-up engineers, and manufacturers in the global pharmaceutical and fine chemical industries who require a reliable supply of high-quality, structurally complex intermediates for innovative drug development.

Application

• Pharmaceutical Intermediate: Primary use as a critical precursor in the synthesis of novel fluoroquinolone antibacterial agents.
• API Synthesis: Serves as a key building block for constructing the core quinoline-piperazine scaffold in target drug molecules.
• Research & Development: Utilized in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new therapeutic candidates.
• Process Chemistry: Employed in route scouting, optimization, and scale-up activities for commercial manufacturing processes.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in pharmaceutical labs.
• Custom Synthesis: A starting point for the custom synthesis of more complex, proprietary derivatives for specialized client projects.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-7-(4-Nitroso-1-Piperazinyl)-4-Oxo-
CAS No.	864443-44-7
Molecular Formula	C₁₇H₁₇FN₄O₄
Molecular Weight	360.34 g/mol
Synonyms	1-Cyclopropyl-6-fluoro-1,4-dihydro-7-(4-nitroso-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid; 7-(4-Nitroso-1-piperazinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid; 1-Cyclopropyl-6-fluoro-7-(4-nitroso-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid; Gatifloxacin Nitroso Impurity; Gatifloxacin N-Oxide Intermediate; Nitroso Gatifloxacin; 864443-44-7 (CAS); Quinolone carboxylic acid derivative
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid derivative is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets stringent specifications for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to meet client-specific requirements or compendial standards (e.g., ICH guidelines).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is strictly light-sensitive (protect from all light exposure) and easily oxidized (store under inert atmosphere). For long-term storage, consider storage under an inert gas (nitrogen or argon) in a freezer (-20°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.