Description

2,4-Dichloro-7-Fluoro-6-Methoxy-Quinazoline is a high-purity, multi-functional heterocyclic building block of significant importance in advanced organic synthesis. Its core value lies in its versatile reactivity, where the strategically positioned chlorine and fluorine atoms serve as excellent handles for selective substitution reactions, enabling the rapid construction of complex molecular architectures. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly kinase inhibitors and other targeted therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of tyrosine kinase inhibitors (TKIs) and other small-molecule drug candidates targeting cancer and inflammatory diseases.
• Agrochemical Research: Used as a core scaffold for developing new herbicides and fungicides, leveraging the bioactivity of the quinazoline moiety.
• Chemical Biology Probe Development: Serves as a starting material for creating labeled compounds or activity-based probes to study enzyme function and biological pathways.
• Material Science Research: Investigated as a building block for organic electronic materials and photoactive compounds due to its conjugated quinazoline structure.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and non-commercial research quantities.

Basic Information

Product Name	2,4-Dichloro-7-Fluoro-6-Methoxy-Quinazoline
CAS No.	864292-37-5
Molecular Formula	C9H5Cl2FN2O
Molecular Weight	247.05 g/mol
Synonyms	6-Methoxy-2,4-dichloro-7-fluoroquinazoline; 7-Fluoro-6-methoxy-2,4-dichloroquinazoline; 2,4-Dichloro-7-fluoro-6-methoxyquinazoline; Quinazoline, 2,4-dichloro-7-fluoro-6-methoxy-; 864292-37-5; FCAS 864292-37-5
EINECS	Contact for details

Quality Control

Our 2,4-Dichloro-7-Fluoro-6-Methoxy-Quinazoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing batch-specific results are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.