Description

Mchr1 Antagonist 2 is a potent and selective small molecule antagonist targeting the melanin-concentrating hormone receptor 1 (MCHR1). This compound is a critical research tool for investigating the role of the MCH system in regulating energy homeostasis, feeding behavior, and mood disorders. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and contract research organizations (CROs) engaged in metabolic and central nervous system (CNS) drug discovery programs.

Application

• Pharmacological Research: Used as a reference standard and active agent in in vitro and in vivo studies to elucidate MCHR1 signaling pathways and physiological functions.
• Drug Discovery & Development: Serves as a key lead compound or chemical probe for developing novel therapeutics targeting obesity, metabolic syndrome, and diabetes.
• Neuroscience Studies: Applied in research models to explore the connection between MCHR1 antagonism, appetite suppression, and potential anti-depressant or anxiolytic effects.
• High-Throughput Screening (HTS): Employed as a control compound in assay development and validation for screening compound libraries against MCHR1.
• Biochemical Assays: Used in receptor binding studies (e.g., competitive radioligand binding assays) and functional assays (e.g., cAMP inhibition) to determine compound potency and selectivity.
• Preclinical Animal Studies: Administered in rodent models to evaluate efficacy in weight reduction, food intake, and related metabolic parameters.

Basic Information

Product Name	Mchr1 Antagonist 2
CAS No.	863115-70-2
Molecular Formula	C₂₀H₂₀ClN₃O₂
Molecular Weight	369.85 g/mol
Synonyms	N-(1H-Benzimidazol-2-ylmethyl)-5-chloro-2-methoxy-N-[(1S)-1-phenylpropyl]benzamide; SNAP 94847; MCH1 receptor antagonist SNAP 94847; 5-Chloro-N-[(1S)-1-phenylpropyl]-2-methoxy-N-(1H-benzimidazol-2-ylmethyl)benzamide; MCHR1 Antagonist; SNAP-94847; MCH1 Antagonist.
EINECS	Contact for details

Quality Control

Our Mchr1 Antagonist 2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing batch-specific results against established specifications. Our quality commitment ensures material integrity for critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.