Description

4-[2-(4-Aminophenoxy)Ethyl]-1-(tert-Butoxycarbonyl)Piperazine is a high-purity, protected piperazine derivative featuring both a Boc-protected amine and a primary aromatic amine. This compound is a critical pharmaceutical intermediate and building block for medicinal chemistry research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for the synthesis of novel active pharmaceutical ingredients (APIs) and complex molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Medicinal Chemistry Research: Used in the design and construction of novel chemical libraries for high-throughput screening (HTS) and structure-activity relationship (SAR) studies.
• Peptidomimetic Synthesis: Serves as a versatile scaffold for creating peptidomimetics and constrained peptide analogs due to its piperazine core and functional handles.
• Linker Chemistry: The differentiated amine groups (protected and free) make it suitable for use in conjugation chemistry and as a linker in prodrug design.
• Chemical Biology Probes: Employed in the development of chemical probes and tool compounds for investigating biological pathways and target validation.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) engaged in custom synthesis projects.

Basic Information

Product Name	4-[2-(4-Aminophenoxy)Ethyl]-1-(tert-Butoxycarbonyl)Piperazine
CAS No.	862874-77-9
Molecular Formula	C17H27N3O3
Molecular Weight	321.42 g/mol
Synonyms	1-Boc-4-[2-(4-aminophenoxy)ethyl]piperazine; tert-Butyl 4-[2-(4-aminophenoxy)ethyl]piperazine-1-carboxylate; 4-(2-(4-Aminophenoxy)ethyl)-1-(tert-butoxycarbonyl)piperazine; 1-N-Boc-4-(2-(4-aminophenoxy)ethyl)piperazine; 4-[2-(4-Aminophenoxy)ethyl]-1-Boc-piperazine; 1-(tert-Butoxycarbonyl)-4-[2-(4-aminophenoxy)ethyl]piperazine; Boc-4-(2-(4-aminophenoxy)ethyl)piperazine
EINECS	Contact for details

Quality Control

Our 4-[2-(4-Aminophenoxy)Ethyl]-1-(tert-Butoxycarbonyl)Piperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.