Description

1-Benzyl-3,3-Difluoropyrrolidine Hydrochloride is a high-purity, fluorinated pyrrolidine derivative offered as a hydrochloride salt, serving as a critical building block in advanced organic synthesis. This compound is valued for its unique chemical structure, which introduces both a benzyl protecting group and difluoromethylene functionality, making it an essential intermediate for medicinal chemistry and drug discovery programs. It is primarily sought by research scientists and process chemists in the pharmaceutical and agrochemical industries for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and metabolic disease targets.
• Medicinal Chemistry Building Block: Used to introduce the difluoropyrrolidine moiety into lead compounds to modulate pharmacokinetic properties like metabolic stability and bioavailability.
• Agrochemical Research: Serves as a precursor in the synthesis of novel pesticides and herbicides, leveraging the fluorine atoms for enhanced biological activity.
• Chemical Biology Probe Development: Employed in the creation of tool compounds and inhibitors for studying enzyme function and biological pathways.
• Process Chemistry & Scale-Up: Supplied for route scouting, optimization, and pilot-scale production of active pharmaceutical ingredients (APIs).
• Academic Research: Used in university and institutional laboratories for methodological studies in fluorination chemistry and heterocycle synthesis.

Basic Information

Product Name	1-Benzyl-3,3-Difluoropyrrolidine Hydrochloride
CAS No.	862416-37-3
Molecular Formula	C11H14ClF2N
Molecular Weight	233.68 g/mol
Synonyms	1-Benzyl-3,3-difluoropyrrolidine hydrochloride; 3,3-Difluoro-1-benzylpyrrolidine hydrochloride; N-Benzyl-3,3-difluoropyrrolidine HCl; Pyrrolidine, 3,3-difluoro-1-(phenylmethyl)-, hydrochloride (1:1); 862416-37-3; 1-(Phenylmethyl)-3,3-difluoropyrrolidine hydrochloride
EINECS	Contact for details

Quality Control

Every batch of 1-Benzyl-3,3-Difluoropyrrolidine Hydrochloride is manufactured under strict quality management systems. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request. We support development and commercial projects with consistent quality, traceability, and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.