Description

1-Naphthalenecarboxamide, n-Cyclopropyl-6-[(6,7-Dimethoxy-4-Quinolinyl)Oxy]- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound matters for its critical role as a key building block in the synthesis of targeted therapeutic agents, particularly in oncology research. Pharmaceutical manufacturers and advanced R&D laboratories need this material for developing novel drug candidates where precise molecular architecture is essential for biological activity. Its synthesis requires stringent control to ensure the integrity of the quinoline and naphthalene moieties.

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the synthesis of targeted kinase inhibitors and other small-molecule therapeutics.
• Oncology Research & Development: Serves as a key precursor in the development of novel anti-cancer drug candidates, leveraging its specific quinolinyloxy scaffold.
• Chemical Biology & Proteomics: Used in the design and synthesis of chemical probes for studying enzyme function and cellular signaling pathways.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale production of active pharmaceutical ingredients (APIs).
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical companies with custom synthesis and development.
• Academic Research: Utilized in university and institutional labs for medicinal chemistry programs and the exploration of new structure-activity relationships.

Basic Information

Product Name	1-Naphthalenecarboxamide, n-Cyclopropyl-6-[(6,7-Dimethoxy-4-Quinolinyl)Oxy]-
CAS No.	861874-34-2
Molecular Formula	C25H22N2O4
Molecular Weight	414.46 g/mol
Synonyms	N-Cyclopropyl-6-[(6,7-dimethoxy-4-quinolinyl)oxy]-1-naphthalenecarboxamide; 6-[(6,7-Dimethoxy-4-quinolinyl)oxy]-N-cyclopropyl-1-naphthamide; Cabozantinib Intermediate; Cabozantinib Impurity; Cabozantinib Related Compound; XL184 Intermediate; BMS-907351 Intermediate; COMETRIQ Intermediate
EINECS	Contact for details

Quality Control

Our 1-Naphthalenecarboxamide, n-Cyclopropyl-6-[(6,7-Dimethoxy-4-Quinolinyl)Oxy]- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the exacting standards required for pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing purity, related substances, and residual solvents is provided with each shipment. Our quality commitment aligns with ICH guidelines and supports regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and purity. Keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.