Description

5-(3,4-Dimethyl-Phenyl)-7-Trifluoromethyl-4,5,6,7-Tetrahydro-Pyrazolo[1,5-A]Pyrimidine is a high-purity, advanced pharmaceutical intermediate belonging to the pyrazolopyrimidine class of heterocyclic compounds. Its molecular architecture, featuring a trifluoromethyl group and a tetrahydro core, makes it a critical building block for the synthesis of novel active pharmaceutical ingredients (APIs) with enhanced metabolic stability and bioavailability. This compound is primarily utilized by research organizations and pharmaceutical manufacturers engaged in drug discovery and development, particularly for targeting central nervous system (CNS) disorders and inflammatory conditions.

Application

This specialized intermediate serves key roles in sophisticated chemical synthesis pipelines.

• Pharmaceutical Intermediate: Core scaffold for the research and development of new drug candidates, especially kinase inhibitors.
• Organic Synthesis Building Block: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Biochemical Research: Serves as a reference standard or a probe molecule in pharmacological assays and target validation.
• Preclinical Development: Employed in the synthesis of compounds for toxicology and pharmacokinetic studies.

Basic Information

Product Name	5-(3,4-Dimethyl-Phenyl)-7-Trifluoromethyl-4,5,6,7-Tetrahydro-Pyrazolo[1,5-A]Pyrimidine
CAS No.	861508-73-8
Molecular Formula	C15H16F3N3
Molecular Weight	295.30 g/mol
Synonyms	5-(3,4-Dimethylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[1,5-a]pyrimidine; 7-Trifluoromethyl-5-(3,4-dimethylphenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[1,5-a]pyrimidine; 4,5,6,7-Tetrahydro-5-(3,4-dimethylphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine; Pyrazolo[1,5-a]pyrimidine, 5-(3,4-dimethylphenyl)-4,5,6,7-tetrahydro-7-(trifluoromethyl)-; 861508-73-8
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support development projects with custom synthesis and purity grades (from research grade to GMP standard) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.