Description

4-Methyl-3-Oxo-3,4-Dihydro-2H-1,4-Benzoxazine-6-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its benzoxazine carboxylic acid structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex heterocyclic scaffolds. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities and proprietary drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Organic Synthesis Research: Serves as a versatile precursor for constructing complex heterocyclic frameworks in medicinal chemistry and process development.
• Agrochemical Development: Used in research for creating new active ingredients with benzoxazine-based structures for crop protection.
• Material Science Research: Investigated as a monomer or additive for developing polymers with specific thermal or optical properties.
• Contract Manufacturing (CMO): Supplied to contract development and manufacturing organizations (CDMOs) for cGMP production of clinical trial materials.

Basic Information

Product Name	4-Methyl-3-Oxo-3,4-Dihydro-2H-1,4-Benzoxazine-6-Carboxylic Acid
CAS No.	861338-27-4
Molecular Formula	C10H9NO4
Molecular Weight	207.18 g/mol
Synonyms	6-Carboxy-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine; 4-Methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carboxylic acid; 2H-1,4-Benzoxazine-6-carboxylic acid, 3,4-dihydro-4-methyl-3-oxo-; 861338-27-4; 4-Methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carboxylic acid
EINECS	Contact for details

Quality Control

Our 4-Methyl-3-Oxo-3,4-Dihydro-2H-1,4-Benzoxazine-6-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents, strong bases, and strong acids. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.