Description

Ethyl 5,7-Dimethyl-2-(Methylsulfonyl)Pyrazolo[1,5-A]Pyrimidine-3-Carboxylate is a high-purity, advanced pharmaceutical intermediate belonging to the pyrazolopyrimidine class of heterocyclic compounds. This compound is valued for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting kinase inhibition. It is essential for research and development laboratories, process chemists, and manufacturers in the pharmaceutical and agrochemical sectors who require reliable, high-quality intermediates for scalable synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates, especially kinase inhibitors for oncology and inflammatory diseases.
• Agrochemical Research: Used in the development of new active ingredients for crop protection products, leveraging its heterocyclic core structure.
• Chemical Synthesis Building Block: Serves as a versatile scaffold for medicinal chemistry and structure-activity relationship (SAR) studies due to its functionalized pyrazolopyrimidine core.
• Academic & Contract Research: Employed in university and CRO (Contract Research Organization) settings for exploratory research in organic and medicinal chemistry.
• Process Development & Scale-Up: Critical for optimizing synthetic routes from laboratory scale to pilot plant and commercial manufacturing.

Basic Information

Product Name	Ethyl 5,7-Dimethyl-2-(Methylsulfonyl)Pyrazolo[1,5-A]Pyrimidine-3-Carboxylate
CAS No.	860464-45-5
Molecular Formula	C13H15N3O4S
Molecular Weight	309.34 g/mol
Synonyms	Ethyl 5,7-dimethyl-2-(methylsulfonyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate; 860464-45-5; 2-(Methylsulfonyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester; Ethyl 2-(methanesulfonyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-carboxylate; Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid, 5,7-dimethyl-2-(methylsulfonyl)-, ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 5,7-Dimethyl-2-(Methylsulfonyl)Pyrazolo[1,5-A]Pyrimidine-3-Carboxylate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring GMP-grade intermediates and aligns with ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider conditions under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.