Description

2-Chloro-6-Fluoro-4-Methoxyquinoline is a high-purity, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique halogenated quinoline scaffold enables precise molecular modifications. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to create new compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors, antimicrobials, and anticancer agents.
• Agrochemical Research: Serves as a building block for developing new generation herbicides, fungicides, and pesticides, leveraging the bioactivity of the quinoline core.
• Material Science: Used in the research and development of advanced organic electronic materials, such as OLEDs and conductive polymers, due to its electron-deficient aromatic structure.
• Chemical Synthesis: Acts as a versatile scaffold for further functionalization via cross-coupling reactions, nucleophilic substitutions, and other transformations to create diverse chemical libraries.
• Dye & Pigment Intermediate: Employed in the synthesis of specialized quinoline-based dyes and fluorescent markers for analytical and industrial applications.

Basic Information

Product Name	2-Chloro-6-Fluoro-4-Methoxyquinoline
CAS No.	860296-85-1
Molecular Formula	C₁₀H₇ClFNO
Molecular Weight	211.62 g/mol
Synonyms	2-Chloro-6-fluoro-4-methoxyquinoline; 4-Methoxy-2-chloro-6-fluoroquinoline; 6-Fluoro-2-chloro-4-methoxyquinoline; Quinoline, 2-chloro-6-fluoro-4-methoxy-; 860296-85-1; 2-Chloro-6-fluoro-4-methoxy-quinoline; 4-Methoxy-2-chloro-6-fluoro-quinoline
EINECS	Contact for details

Quality Control

Our 2-Chloro-6-Fluoro-4-Methoxyquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We adhere to cGMP principles for pharmaceutical intermediates, ensuring traceability and reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.