Description

4-(Bromomethyl)-3-(Trifluoromethyl)Benzoic Acid is a high-value, multi-functional aromatic building block that combines a reactive bromomethyl group with a trifluoromethyl-substituted benzoic acid core. This compound is essential for introducing both lipophilic and electron-withdrawing characteristics into target molecules, enabling the synthesis of advanced materials and active pharmaceutical ingredients. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer Modification: Employed to introduce functional side chains into polymers, altering their physical properties for specialized coatings and high-performance plastics.
• Cross-Coupling Reactions: The bromomethyl moiety acts as an excellent handle for further functionalization via Suzuki, Sonogashira, or other palladium-catalyzed cross-coupling reactions.
• Ligand & Catalyst Development: Useful for synthesizing novel chelating ligands and organocatalysts used in asymmetric synthesis.

Basic Information

Item	Details
Product Name	4-(Bromomethyl)-3-(Trifluoromethyl)Benzoic Acid
CAS No.	859213-39-1
Molecular Formula	C9H6BrF3O2
Molecular Weight	283.04 g/mol
Synonyms	3-(Trifluoromethyl)-4-(bromomethyl)benzoic acid; 4-Bromomethyl-3-trifluoromethylbenzoic acid; Benzoic acid, 4-(bromomethyl)-3-(trifluoromethyl)-; α-Bromo-3-trifluoromethyl-p-toluic acid; 4-(Bromomethyl)-α,α,α-trifluoro-m-toluic acid; 3-Trifluoromethyl-4-bromomethylbenzoic acid; 4-Bromomethyl-α,α,α-trifluoro-m-toluic acid
EINECS	Contact for details

Quality Control

Our production of 4-(Bromomethyl)-3-(Trifluoromethyl)Benzoic Acid adheres to stringent in-process controls and final release specifications to ensure batch-to-batch consistency and reliability. Every lot is analyzed using advanced techniques including HPLC, GC, and NMR to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is kept sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.