Description

4-(3-Chloro-4-(((Cyclopropylamino)Carbonyl)Amino)Phenoxy)-7-Methoxy-6-Quinolinecarboxamide Monohydrochloride is a high-purity, small molecule pharmaceutical intermediate and research chemical. This compound is of significant value for its role as a key building block in the synthesis of targeted therapeutic agents. It is primarily required by pharmaceutical R&D departments, contract research organizations (CROs), and fine chemical manufacturers engaged in advanced drug discovery and development programs.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of novel kinase inhibitors and other targeted small molecule drugs.
• Biochemical Research: Used as a reference standard and active compound in high-throughput screening (HTS) and mechanism-of-action studies.
• Preclinical Development: Serves as a starting material or intermediate for producing compounds used in pharmacological and toxicological evaluations.
• Academic Research: Utilized in university and institutional labs for chemical biology and medicinal chemistry projects exploring new therapeutic pathways.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	4-(3-Chloro-4-(((Cyclopropylamino)Carbonyl)Amino)Phenoxy)-7-Methoxy-6-Quinolinecarboxamide Monohydrochloride
CAS No.	857890-31-4
Molecular Formula	C21H20ClN5O4 • HCl
Molecular Weight	486.33 g/mol (monohydrochloride salt)
Synonyms	N-[3-Chloro-4-[[[(cyclopropylamino)carbonyl]amino]phenoxy]-7-methoxy-4-quinolinecarboxamide hydrochloride; 6-Quinolinecarboxamide, 4-[3-chloro-4-[[(cyclopropylamino)carbonyl]amino]phenoxy]-7-methoxy-, monohydrochloride; Foretinib Intermediate; GSK1363089 Intermediate; XL880 Intermediate; EXEL-2880 Intermediate; 857890-31-4 (CAS)
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Each batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and LC-MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Single Maximum Impurity	≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.