Description

Kynurenic Acid, 3-Chloro- (5Ci) is a halogenated derivative of the endogenous tryptophan metabolite kynurenic acid, serving as a valuable chemical reference standard and synthetic intermediate. This compound is of significant interest for advanced research in neurochemistry and pharmacology, particularly in studies related to the kynurenine pathway and glutamate receptor modulation. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and specialty chemical manufacturers focused on developing novel therapeutic agents and biochemical tools.

Application

• Pharmaceutical Reference Standard: Used for method development, validation, and quality control in the analysis of kynurenine pathway metabolites.
• Biochemical Research: Acts as a key intermediate or analog in studies investigating NMDA receptor antagonism and neuroprotective mechanisms.
• Metabolite Synthesis: Serves as a building block for the synthesis of more complex, labeled (e.g., deuterated) or modified kynurenic acid derivatives for tracer studies.
• Academic & Discovery Chemistry: Employed in medicinal chemistry programs to explore structure-activity relationships (SAR) for new central nervous system (CNS) targets.
• Diagnostic Development: Potential use in calibrating assays for metabolic disorder screening or inflammatory biomarker detection.

Basic Information

Product Name	Kynurenic Acid, 3-Chloro- (5Ci)
CAS No.	855634-17-2
Molecular Formula	C10H6ClNO3
Molecular Weight	223.61 g/mol
Synonyms	3-Chlorokynurenic Acid; 3-Chloro-4-hydroxyquinoline-2-carboxylic Acid; 3-Cl-KYNA; 3-Chloro-KYNA; 3-Chlorokynurenate; 5Ci-labeled Kynurenic Acid derivative; Quinoline-2-carboxylic acid, 3-chloro-4-hydroxy-
EINECS	Contact for details

Quality Control

Our Kynurenic Acid, 3-Chloro- (5Ci) is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity confirmation and spectroscopic methods (NMR, MS) for structural verification, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) containing batch-specific data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.