Description

Fmoc-2-Amino-4,5-Dimethoxybenzoic Acid is a protected amino acid derivative widely used as a key building block in solid-phase peptide synthesis (SPPS). This compound is essential for the controlled introduction of a modified tyrosine-like aromatic amino acid into peptide chains, enabling the creation of complex biomolecules. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic research laboratories developing novel peptide-based therapeutics, diagnostics, and research tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental reagent for the automated, stepwise construction of custom peptides.
• Pharmaceutical Research: Used in the development of peptide drugs, hormone analogs, and enzyme inhibitors where the 4,5-dimethoxybenzoic acid moiety is required for bioactivity or stability.
• Chemical Biology & Proteomics: Serves as a building block for synthesizing peptide probes, affinity tags, and activity-based protein profiling (ABPP) reagents.
• Material Science: Can be incorporated into peptide-based polymers or hydrogels to impart specific chemical and physical properties.
• Antibody-Drug Conjugate (ADC) Development: Potential use in synthesizing specialized linker-payload components for targeted cancer therapies.
• Academic Research: A critical reagent for studying peptide structure-function relationships and for teaching advanced organic synthesis and peptide chemistry.

Basic Information

Product Name	Fmoc-2-Amino-4,5-Dimethoxybenzoic Acid
CAS No.	855005-12-8
Molecular Formula	C24H21NO7
Molecular Weight	435.43 g/mol
Synonyms	Fmoc-2-Amino-4,5-dimethoxybenzoic acid; 9-Fluorenylmethyl N-(2-carboxy-4,5-dimethoxyphenyl)carbamate; 4,5-Dimethoxy-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]benzoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4,5-dimethoxyanthranilic acid; Fmoc-Dmab-OH; Fmoc-4,5-Dimethoxy-2-aminobenzoic Acid; N-Fmoc-2-amino-4,5-dimethoxybenzoic acid
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques to guarantee identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications such as HPLC purity, chiral purity, and residual solvent content are available upon request. We adhere to cGMP principles for production where applicable to support our clients in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment. For long-term storage, consider desiccation and storage under an inert atmosphere to maintain optimal stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.