Description

2-(4-Chlorophenyl)Quinoline-4-Carbonyl Chloride is a high-purity organic intermediate featuring a reactive acid chloride functional group. This compound is critically important for the synthesis of more complex quinoline-based molecules, serving as a key building block in pharmaceutical and advanced material research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries to introduce the 2-(4-chlorophenyl)quinoline-4-carbonyl moiety into target structures.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting various disease pathways where the quinoline scaffold is pharmacologically active.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the chlorophenyl-quinoline structure.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in catalytic processes and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of organic electronic materials, such as charge-transport layers or light-emitting components, due to its conjugated aromatic system.
• Fluorescent Probe and Dye Synthesis: Acts as a core structure for developing fluorescent markers and dyes used in biochemical assays and imaging.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific custom synthesis projects.

Basic Information

Product Name	2-(4-Chlorophenyl)Quinoline-4-Carbonyl Chloride
CAS No.	854864-03-2
Molecular Formula	C16H9Cl2NO
Molecular Weight	302.15 g/mol
Synonyms	4-Chlorobenzoyl-2-chloroquinoline; 2-(p-Chlorophenyl)-4-quinolinecarbonyl chloride; Quinoline-4-carbonyl chloride, 2-(4-chlorophenyl)-; 2-(4-Chlorophenyl)quinoline-4-carboxylic acid chloride; 854864-03-2; 2-(4-Chlorophenyl)-4-quinolinecarbonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 2-(4-Chlorophenyl)Quinoline-4-Carbonyl Chloride is manufactured and tested under a strict quality management system. We ensure the product meets high-purity standards suitable for research and development applications. Comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, is performed to confirm identity and purity. A Certificate of Analysis (COA) detailing all test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Recommended storage temperature is 2-8°C for long-term stability. Keep away from heat, sparks, open flames, and strong bases.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.