Description

1-(4-Aminophenyl)Cyclopropanecarboxylic Acid is a specialized organic compound featuring a cyclopropane ring fused to an aromatic amine-substituted carboxylic acid, making it a valuable bifunctional building block. This unique structure provides two distinct reactive sites, enabling its use in the synthesis of complex molecules with specific spatial and electronic properties. It is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and plant growth regulators, leveraging its rigid cyclopropane scaffold.
• Ligand and Catalyst Development: Serves as a starting material for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of advanced polymers, liquid crystals, and organic electronic materials due to its conjugated amine-acid structure.
• Chemical Biology Probes: Utilized to synthesize molecular probes and tags for studying biological processes and protein interactions.
• Custom Synthesis & Contract Manufacturing: A critical building block for custom synthesis projects and scale-up manufacturing under cGMP conditions for clinical trial materials.

Basic Information

Product Name	1-(4-Aminophenyl)Cyclopropanecarboxylic Acid
CAS No.	854821-21-9
Molecular Formula	C10H11NO2
Molecular Weight	177.20 g/mol
Synonyms	4-(1-Carboxycyclopropyl)aniline; 1-(4-Aminophenyl)cyclopropane-1-carboxylic Acid; 4-(Aminophenyl)cyclopropanecarboxylic Acid; p-Aminophenylcyclopropanecarboxylic Acid; Cyclopropanecarboxylic acid, 1-(4-aminophenyl)-; 1-(p-Aminophenyl)cyclopropanecarboxylic Acid; 4-(Cyclopropanecarbonyl)aniline (tautomeric form); ACPCA
EINECS	Contact for details

Quality Control

Our 1-(4-Aminophenyl)Cyclopropanecarboxylic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or production specifications. Custom purity grades, including pharmaceutical intermediates suitable for further GMP processing, are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which may affect stability and performance. For long-term storage, consider using a desiccant in the storage environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.