Description

3-Bromo-4-Hydroxy-8-Trifluoromethylquinoline is a high-purity, multifunctional heterocyclic building block of significant interest in advanced organic synthesis. Its unique molecular architecture, featuring bromo, hydroxy, and trifluoromethyl substituents on the quinoline core, makes it a versatile intermediate for constructing complex molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly for targets requiring halogenated and fluorinated quinoline scaffolds.
• Agrochemical Research: Used in developing new generation herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science: Serves as a building block for organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components in organic light-emitting diodes (OLEDs).
• Chemical Synthesis: Utilized in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic substitutions due to the reactive bromo substituent.
• Fluorine Chemistry Studies: An important compound for research into the effects of fluorine substitution on the physicochemical properties of heterocycles.
• Ligand and Catalyst Development: The hydroxy and nitrogen donor sites make it a candidate for designing novel chelating ligands in coordination chemistry and catalysis.

Basic Information

Product Name	3-Bromo-4-Hydroxy-8-Trifluoromethylquinoline
CAS No.	854778-26-0
Molecular Formula	C₁₀H₅BrF₃NO
Molecular Weight	292.06 g/mol
Synonyms	8-Trifluoromethyl-3-bromo-4-hydroxyquinoline; 3-Bromo-4-hydroxy-8-(trifluoromethyl)quinoline; 4-Hydroxy-3-bromo-8-trifluoromethylquinoline; Quinoline, 3-bromo-4-hydroxy-8-(trifluoromethyl)-; 854778-26-0; 3-Bromo-4-hydroxy-8-trifluoromethyl-quinoline
EINECS	Contact for details

Quality Control

Our 3-Bromo-4-Hydroxy-8-Trifluoromethylquinoline is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.