Description

3-Methyl-5-(Trifluoromethyl)-1H-Indole-2-Carboxylic Acid CAS NO 854531-37-6 is a high-value, multi-functional indole derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both a carboxylic acid group and a trifluoromethyl substituent, makes it an essential intermediate for creating novel compounds with enhanced biological activity and physicochemical properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel drug candidates, particularly in areas like kinase inhibitors, anti-inflammatory agents, and central nervous system (CNS) therapeutics.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the trifluoromethyl group can improve metabolic stability and lipophilicity.
• Material Science Research: Acts as a precursor for functionalized organic materials, including ligands for catalysis and monomers for specialty polymers.
• Chemical Biology & Proteomics: Employed as a scaffold or labeling agent in the design of molecular probes and activity-based protein profiling (ABPP) reagents.
• Academic & Contract Research: Serves as a versatile starting material for methodological development and the synthesis of complex heterocyclic libraries in academic and CRO settings.

Basic Information

Product Name	3-Methyl-5-(Trifluoromethyl)-1H-Indole-2-Carboxylic Acid
CAS No.	854531-37-6
Molecular Formula	C11H8F3NO2
Molecular Weight	243.18 g/mol
Synonyms	3-Methyl-5-(trifluoromethyl)-1H-indole-2-carboxylic acid; 5-(Trifluoromethyl)-3-methyl-1H-indole-2-carboxylic acid; 1H-Indole-2-carboxylic acid, 3-methyl-5-(trifluoromethyl)-; 3-Methyl-5-trifluoromethylindole-2-carboxylic acid; 2-Carboxy-3-methyl-5-trifluoromethylindole; MFCD23115481; ZINC000103254757
EINECS	Contact for details

Quality Control

Our production of 3-Methyl-5-(Trifluoromethyl)-1H-Indole-2-Carboxylic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for research and scale-up applications. All materials are characterized by modern analytical techniques including HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.