Description

1,2-Bis((2R,5R)-2,5-Dimethylphospholano)Ethane(Cyclooctadiene)Rhodium(I) Trifluoromethanesulfonate is a high-value, chiral organometallic catalyst essential for advanced asymmetric synthesis. This compound, with CAS number 854275-87-9, is prized for its exceptional enantioselectivity and catalytic activity in key carbon-carbon and carbon-heteroatom bond-forming reactions. It is a critical reagent for R&D and production chemists in the pharmaceutical, agrochemical, and fine chemical industries seeking to produce single-enantiomer intermediates and active ingredients.

Application

• Asymmetric Hydrogenation: A premier catalyst for the enantioselective reduction of prochiral olefins, enamines, and ketones to produce chiral alcohols and amines with high optical purity.
• Pharmaceutical Intermediate Synthesis: Enables the efficient, scalable production of single-enantiomer active pharmaceutical ingredients (APIs) and key chiral building blocks.
• Agrochemical Manufacturing: Used in the synthesis of chiral herbicides, fungicides, and pesticides where biological activity is enantiomer-specific.
• Fine Chemical Production: Facilitates the creation of complex, high-value specialty chemicals, flavors, and fragrances requiring precise stereochemistry.
• Academic & Industrial R&D: A vital tool for method development and discovery chemistry in asymmetric catalysis and process optimization.
• Catalyst Ligand Precursor: Serves as a source for the chiral DuPHOS-type ligand framework in custom catalyst design and immobilization studies.

Basic Information

Product Name	1,2-Bis((2R,5R)-2,5-Dimethylphospholano)Ethane(Cyclooctadiene)Rhodium(I) Trifluoromethanesulfonate
CAS No.	854275-87-9
Molecular Formula	C₂₂H₃₈F₃O₃P₂RhS
Molecular Weight	628.44 g/mol
Synonyms	(R,R)-Me-DuPHOS-Rh(COD)OTf; [(R,R)-Me-DuPHOS)Rh(COD)]OTf; (R,R)-1,2-Bis(2,5-dimethylphospholano)ethane(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; Rhodium(I)-(R,R)-Me-DuPHOS-COD triflate; (R,R)-Me-DuPHOS Rhodium(I) Cyclooctadiene Triflate; Asymmetric Hydrogenation Catalyst (R,R)-Me-DuPHOS-Rh; [Rh((R,R)-Me-DuPHOS)(COD)]OTf
EINECS	Contact for details

Quality Control

Every batch of our 1,2-Bis((2R,5R)-2,5-Dimethylphospholano)Ethane(Cyclooctadiene)Rhodium(I) Trifluoromethanesulfonate is manufactured and handled under strict inert atmosphere conditions to preserve its catalytic integrity. We employ advanced analytical techniques including NMR, HPLC, and elemental analysis to verify identity, chiral purity, and catalytic activity. A comprehensive Certificate of Analysis (COA) detailing assay, enantiomeric excess (ee) of derived products, and impurity profiles is provided with each shipment to ensure it meets the exacting standards required for asymmetric synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to minimize oxidation and decomposition. Allow the sealed container to reach room temperature before opening to prevent moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Orange to red-brown solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Rhodium Content	Contact for details
Catalytic Activity Test	≥ 95% ee (model reaction)
Solubility	Soluble in dichloromethane, THF; sparingly soluble in toluene

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.