Description

4-Aminobicyclo[2.2.2]octane-1-carboxylic acid hydrochloride is a high-purity, functionalized bicyclic amino acid derivative, serving as a critical chiral building block in advanced organic synthesis. Its rigid, three-dimensional bicyclo[2.2.2]octane scaffold provides unique steric and electronic properties, enabling the development of novel compounds with enhanced biological activity and stability. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for constructing complex molecular architectures in drug discovery and the synthesis of specialized fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and metabolic disorder therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where its structural rigidity can improve target specificity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetics and Bioactive Molecule Design: The constrained amino acid structure is valuable for designing peptide analogs and other bioactive molecules with improved pharmacokinetic profiles.
• Material Science Research: Investigated as a monomer or additive for creating polymers with specific mechanical or optical properties.
• Academic and R&D Laboratories: A valuable reagent for methodological studies in organic chemistry and medicinal chemistry research programs.

Basic Information

Product Name	4-Aminobicyclo[2.2.2]octane-1-carboxylic acid hydrochloride
CAS No.	854214-59-8
Molecular Formula	C9H16ClNO2
Molecular Weight	205.68 g/mol
Synonyms	1-Aminobicyclo[2.2.2]octane-4-carboxylic acid hydrochloride; 4-Amino-1-carboxybicyclo[2.2.2]octane hydrochloride; Bicyclo[2.2.2]octane-1-carboxylic acid, 4-amino-, hydrochloride; 4-ABOCH; 4-Aminobicyclo[2.2.2]octane-1-carboxylic acid HCl; (1s,4s)-4-Aminobicyclo[2.2.2]octane-1-carboxylic acid hydrochloride
EINECS	Contact for details

Quality Control

Our 4-Aminobicyclo[2.2.2]octane-1-carboxylic acid hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available for all shipments. We can support development projects with custom purity grades and analytical method development upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and may require storage under an inert atmosphere for long-term stability. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay (Titration)	97.0% - 102.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.