Description

Chloro(2-Dicyclohexylphosphino-2',6'-Dimethoxy-1,1'-Biphenyl)Gold(I), 98% is a high-purity, air-stable gold(I) complex featuring the SPhos ligand, a prominent member of the Buchwald phosphine ligand family. This compound is a highly effective and selective catalyst for a range of cross-coupling and addition reactions, offering superior performance in challenging transformations. It is an essential reagent for academic research and industrial R&D in pharmaceutical, agrochemical, and advanced materials synthesis, where precise catalytic control is paramount.

Application

• Catalyst for C–N, C–O, and C–C Cross-Coupling Reactions: Enables efficient Buchwald-Hartwig amination and Suzuki-Miyaura coupling, crucial for constructing complex molecules in drug discovery.
• Pharmaceutical Intermediate Synthesis: Used in the development and scale-up of active pharmaceutical ingredients (APIs) requiring gold-catalyzed steps.
• Hydroamination and Hydroarylation: Catalyzes the addition of N–H and C–H bonds across unsaturated bonds for streamlined synthesis.
• Materials Science Research: Facilitates the synthesis of novel organic electronic materials and polymers via controlled coupling reactions.
• Methodology Development in Academia: A key tool for chemists developing new catalytic cycles and reaction methodologies.
• Fine Chemical Production: Applied in the manufacture of high-value, complex specialty chemicals for various industries.

Basic Information

Product Name	Chloro(2-Dicyclohexylphosphino-2',6'-Dimethoxy-1,1'-Biphenyl)Gold(I), 98%
CAS No.	854045-95-7
Molecular Formula	C32H41AuClO2P
Molecular Weight	721.06 g/mol
Synonyms	Chloro[2-dicyclohexylphosphino-2',6'-dimethoxy-1,1'-biphenyl]gold(I); Chloro(SPhos)gold(I); SPhos Gold(I) Chloride; [2-(Dicyclohexylphosphino)-2',6'-dimethoxybiphenyl]chlorogold(I); Gold(I) SPhos Chloride; Au-SPhos-Cl; (SPhos)AuCl; Chloro[2-(dicyclohexylphosphino)-2',6'-dimethoxy-1,1'-biphenyl]gold
EINECS	Contact for details

Quality Control

Our 98% purity grade of Chloro(SPhos)gold(I) is produced under stringent quality protocols. Each batch undergoes comprehensive analytical testing, including NMR (¹H, ³¹P) and HPLC analysis, to confirm identity, purity, and catalytic suitability. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a cool, dry place. This material is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air and moisture should be avoided to maintain catalytic activity.

Specification

Item	Specification
Appearance	Off-white to yellow powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Gold (Au) Content	27.0 - 28.0 %
Solubility	Soluble in common organic solvents (DCM, THF, Toluene)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.