Description

(2-Biphenyl)Di-tert-Butylphosphine Gold& CAS NO 854045-93-5 is a high-value, specialized organophosphine ligand widely used in advanced catalytic processes. Its primary value lies in its exceptional electron-donating properties and steric bulk, which significantly enhance the activity and selectivity of transition metal catalysts, particularly for challenging cross-coupling reactions. This makes it an indispensable component for R&D and production in the pharmaceutical, agrochemical, and advanced materials sectors, where precise molecular construction is critical.

Application

• Pharmaceutical Intermediate Synthesis: As a key ligand in Buchwald-Hartwig amination, Suzuki-Miyaura, and other palladium-catalyzed cross-couplings for constructing complex drug molecules.
• Agrochemical Manufacturing: Enabling efficient synthesis of novel active ingredients through catalytic C-C and C-N bond formation.
• Materials Science R&D: Facilitating the development of organic electronic materials, polymers, and liquid crystals via metal-catalyzed polymerization and functionalization.
• Academic & Industrial Catalysis Research: Serving as a premium ligand for developing new catalytic methodologies and optimizing reaction conditions.
• Fine Chemical Production: Used in the synthesis of specialty chemicals, flavors, and fragrances requiring high-purity catalytic steps.
• Homogeneous Catalyst Preparation: A precursor for generating in-situ or pre-formed palladium, gold, and other transition metal complexes.

Basic Information

Item	Detail
Product Name	(2-Biphenyl)Di-tert-Butylphosphine Gold& CAS NO 854045-93-5
CAS No.	854045-93-5
Molecular Formula	C20H27P
Molecular Weight	298.40 g/mol
Synonyms	Di-tert-butyl(2-biphenylyl)phosphine; JohnPhos; (2-Biphenylyl)di-tert-butylphosphine; (2-Biphenyl)Di-tert-butylphosphine; DTBPB; t-Bu-JohnPhos; 2-(Di-tert-butylphosphino)biphenyl; Ligand: JohnPhos
EINECS	Contact for details

Quality Control

Our (2-Biphenyl)Di-tert-Butylphosphine Gold& CAS NO 854045-93-5 is manufactured under strict quality protocols to ensure batch-to-batch consistency and high performance in sensitive catalytic applications. Each lot undergoes comprehensive analysis, including HPLC for purity and NMR for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, identity, and impurity profiles to meet the stringent requirements of our global clientele.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Due to its sensitivity to oxidation, the container should only be opened in an inert glovebox or under a positive pressure of inert gas.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.