Description

Carbamic Acid, [1-(4-Quinazolinyl)-3-Azetidinyl]-, 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a unique quinazoline-azetidine hybrid scaffold. This compound is of significant commercial interest for its role as a key building block in the research and development of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on oncology, kinase inhibitors, and other targeted small-molecule drug discovery programs.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates, particularly those targeting protein kinases.
• Oncology Research: Serves as a core structural component for developing novel anti-cancer compounds due to the biological relevance of the quinazoline moiety.
• Chemical Biology Probes: Used in the design and synthesis of molecular probes for studying enzyme function and cellular signaling pathways.
• Process Chemistry & Scale-Up: Employed in process development and optimization for the commercial manufacturing of active pharmaceutical ingredients (APIs).
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs offering bespoke chemical synthesis services.
• Library Synthesis: Facilitates the creation of diverse compound libraries for high-throughput screening in drug discovery campaigns.

Basic Information

Product Name	Carbamic Acid, [1-(4-Quinazolinyl)-3-Azetidinyl]-, 1,1-Dimethylethyl Ester
CAS No.	853680-52-1
Molecular Formula	C17H20N4O2
Molecular Weight	312.37 g/mol
Synonyms	tert-Butyl 1-(quinazolin-4-yl)azetidine-3-carboxylate; 1,1-Dimethylethyl 1-(4-quinazolinyl)-3-azetidinecarboxylate; 1-(Quinazolin-4-yl)azetidine-3-carboxylic acid tert-butyl ester; 4-(3-(tert-Butoxycarbonyl)azetidin-1-yl)quinazoline; BOC-Azetidine-Quinazoline Intermediate; Azetidine-3-carboxylic acid, 1-(4-quinazolinyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Every batch of Carbamic Acid, [1-(4-Quinazolinyl)-3-Azetidinyl]-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure compliance with exacting purity standards suitable for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.