Description

tert-Butyl n-[1-(Quinazolin-4-Yl)Piperidin-4-Yl]Carbamate is a high-purity, advanced pharmaceutical intermediate of significant importance in modern drug discovery and development. This compound serves as a critical building block for the synthesis of targeted therapeutic agents, particularly in oncology and other disease areas. It is primarily required by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of novel small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and production of novel drug candidates, especially kinase inhibitors.
• Oncology Research: Used in the development of targeted cancer therapies due to its quinazoline-piperidine scaffold, a common pharmacophore in many anticancer agents.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and lead optimization processes to improve drug potency and selectivity.
• API Synthesis: Serves as a building block in the multi-step synthesis of Active Pharmaceutical Ingredients (APIs) for preclinical and clinical trials.
• Biochemical Research: Utilized as a tool compound or reference standard in biochemical assays to study enzyme inhibition and cellular pathways.
• Custom Synthesis: A starting material for the contract manufacturing of specialized, non-commercial compounds for client-specific research programs.

Basic Information

Product Name	tert-Butyl n-[1-(Quinazolin-4-Yl)Piperidin-4-Yl]Carbamate
CAS No.	853680-03-2
Molecular Formula	C18H24N4O2
Molecular Weight	328.41 g/mol
Synonyms	4-Piperidinamine, 1-(4-quinazolinyl)-, 1,1-dimethylethyl ester; tert-Butyl (1-(quinazolin-4-yl)piperidin-4-yl)carbamate; 1-(Quinazolin-4-yl)piperidin-4-amine, N-Boc-protected; BOC-Piperidine-Quinazoline intermediate; 853680-03-2; 4-[[(tert-Butoxy)carbonyl]amino]-1-(4-quinazolinyl)piperidine
EINECS	Contact for details

Quality Control

Our tert-Butyl n-[1-(Quinazolin-4-Yl)Piperidin-4-Yl]Carbamate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect this light-sensitive material from prolonged exposure.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.