Description

(R)-2-Hydroxy-2-Methyl(4-Nitrobenzene)Acetic Acid is a high-purity chiral intermediate of significant importance in asymmetric synthesis and pharmaceutical development. Its value lies in its role as a key building block for creating optically active compounds, particularly in the synthesis of active pharmaceutical ingredients (APIs) and fine chemicals. This product is essential for research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require enantiomerically pure materials for advanced R&D and production.

Application

• Pharmaceutical Intermediate: A crucial chiral building block for the synthesis of novel Active Pharmaceutical Ingredients (APIs) and drug candidates.
• Asymmetric Synthesis: Used as a starting material or resolving agent in stereoselective chemical reactions to produce single enantiomer products.
• Agrochemical Research: Serves as a precursor in the development of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Ligand and Catalyst Development: Employed in the preparation of chiral ligands and organocatalysts for catalytic asymmetric transformations.
• Fine Chemical Synthesis: Utilized in the multi-step synthesis of complex, high-value specialty chemicals and flavors & fragrances.
• Academic and R&D Laboratories: A valuable reagent for methodological studies in organic chemistry and medicinal chemistry research programs.

Basic Information

Product Name	(R)-2-Hydroxy-2-Methyl(4-Nitrobenzene)Acetic Acid
CAS No.	852630-38-7
Molecular Formula	C10H11NO5
Molecular Weight	225.20 g/mol
Synonyms	(R)-2-Hydroxy-2-(4-nitrophenyl)propanoic acid; (R)-α-Hydroxy-4-nitrohydratropic acid; (R)-2-Methyl-2-hydroxy-2-(4-nitrophenyl)acetic acid; (R)-O-Desmethyl Venlafaxine impurity; (R)-4-Nitro-α-methylmandelic acid; (R)-2-(4-Nitrophenyl)-2-hydroxypropanoic acid
EINECS	Contact for details

Quality Control

Our (R)-2-Hydroxy-2-Methyl(4-Nitrobenzene)Acetic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis (HPLC), to ensure it meets the high standards required for pharmaceutical and advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat sources and incompatible materials. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.