Description

4-Chloro-3-Fluoro-7-Methoxyquinoline is a high-purity, multi-functional heterocyclic building block of significant importance in advanced organic synthesis. Its unique halogenated quinoline structure makes it a critical intermediate for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in the development of kinase inhibitors, antibacterial agents, and other biologically active quinoline derivatives.
• Agrochemical Research: Serves as a core building block for creating new-generation fungicides, herbicides, and pesticides with enhanced efficacy and selectivity.
• Material Science Precursor: Used in the development of organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to the electron-accepting properties of the quinoline core.
• Chemical Synthesis Reagent: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic substitution reactions to introduce the quinoline scaffold into more complex molecules.
• Dye and Pigment Intermediate: Acts as a precursor for the synthesis of specialized quinoline-based dyes and fluorescent markers.

Basic Information

Product Name	4-Chloro-3-Fluoro-7-Methoxyquinoline
CAS No.	852062-11-4
Molecular Formula	C₁₀H₇ClFNO
Molecular Weight	211.62 g/mol
Synonyms	4-Chloro-3-fluoro-7-methoxyquinoline; 7-Methoxy-4-chloro-3-fluoroquinoline; 3-Fluoro-4-chloro-7-methoxyquinoline; 852062-11-4; Quinoline, 4-chloro-3-fluoro-7-methoxy-; 4-Chloro-3-fluoro-7-methoxy-quinoline
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-3-Fluoro-7-Methoxyquinoline is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We adhere to cGMP standards where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.