Description

2,5-Difluoropyridine-4-Carboxylic Acid is a high-purity fluorinated pyridine derivative serving as a critical building block in advanced organic synthesis. This compound is valued for its ability to introduce both fluorine atoms and a carboxylic acid functional group into target molecules, enabling precise modulation of their physicochemical and biological properties. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infective agents.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoropyridine moiety can enhance bioavailability and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis, useful in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials due to its aromatic and fluorinated structure.
• Custom Synthesis and Contract Manufacturing: An essential starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2,5-Difluoropyridine-4-Carboxylic Acid
CAS No.	851386-39-5
Molecular Formula	C6H3F2NO2
Molecular Weight	159.09 g/mol
Synonyms	4-Pyridinecarboxylic acid, 2,5-difluoro-; 2,5-Difluoroisonicotinic acid; 2,5-Difluoropyridine-4-carboxylic acid; 2,5-Difluoro-4-pyridinecarboxylic acid; 2,5-Difluoro-4-carboxypyridine; Difluoropyridinecarboxylic acid; 851386-39-5
EINECS	Contact for details

Quality Control

Our 2,5-Difluoropyridine-4-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets exacting standards for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent batch-to-batch quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and performance. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.