Description

5-(4-Trifluoromethoxyphenyl)-Picolinic Acid is a high-value, multi-functional organic building block characterized by its picolinic acid core and trifluoromethoxy-substituted aromatic ring. This compound matters for its role as a critical intermediate in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where its unique structure imparts desirable physicochemical properties. It is primarily needed by research and development teams, process chemists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel compounds with enhanced performance characteristics.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and production of novel drug candidates, particularly in areas targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides, where the trifluoromethoxy group can improve biological activity and environmental stability.
• Ligand for Catalysis: Acts as a precursor for creating specialized ligands in transition metal catalysis, facilitating challenging synthetic transformations.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as ligands for OLEDs or components for molecular sensors.
• Chemical Biology Probe Development: Utilized as a building block to create tool compounds for studying biological pathways and protein functions.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	5-(4-Trifluoromethoxyphenyl)-Picolinic Acid
CAS No.	851266-72-3
Molecular Formula	C14H8F3NO3
Molecular Weight	295.21 g/mol
Synonyms	5-[4-(Trifluoromethoxy)phenyl]pyridine-2-carboxylic acid; 2-Pyridinecarboxylic acid, 5-[4-(trifluoromethoxy)phenyl]-; 5-(4-Trifluoromethoxyphenyl)picolinate; 5-(4-(Trifluoromethoxy)phenyl)picolinic acid; Picolinic acid, 5-(4-trifluoromethoxyphenyl)-; 851266-72-3; 5-(4-Trifluoromethoxyphenyl)-2-pyridinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 5-(4-Trifluoromethoxyphenyl)-Picolinic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure compliance with stringent industry standards. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.