Description

o-Acetyl-n-tert-Butylhydroxylamine Hydrochloride is a high-purity, protected hydroxylamine derivative used as a critical building block and reagent in advanced organic synthesis. This compound is valued for its role in introducing the tert-butyloxycarbonyl (Boc) protected hydroxylamine functionality, which is essential for constructing complex molecules with controlled reactivity. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of hydroxamic acids, which are important pharmacophores in drug discovery for enzyme inhibition (e.g., HDAC inhibitors).
• Peptide & Protein Modification: Used to introduce protected hydroxylamine groups for site-specific conjugation, labeling, or cross-linking in bioconjugation chemistry.
• Agrochemical Synthesis: Intermediate in the production of novel herbicides, fungicides, and plant growth regulators that require hydroxylamine-derived structures.
• Polymer Chemistry: Serves as a functional monomer or chain-transfer agent for creating polymers with tailored properties, such as stimuli-responsive materials.
• Organic Synthesis Reagent: Employed in nucleophilic addition reactions and as a precursor to various N-O containing functional groups under controlled conditions.
• Chemical Biology Probes: Utilized in the development of activity-based probes and affinity labels for studying biological pathways and target engagement.

Basic Information

Product Name	o-Acetyl-n-tert-Butylhydroxylamine Hydrochloride
CAS No.	851074-40-3
Molecular Formula	C6H14ClNO2
Molecular Weight	167.63 g/mol
Synonyms	N-(tert-Butoxy)-N-acetoxyamine Hydrochloride; N-Acetoxy-tert-butylamine Hydrochloride; O-Acetyl-N-(tert-butyl)hydroxylamine Hydrochloride; N-tert-Butyl-O-acetylhydroxylamine Hydrochloride; Acetyl tert-butylhydroxylamine Hydrochloride; Boc-Protected Hydroxylamine Hydrochloride (Acetyl Form); tert-Butyl N-(Acetoxy)carbamate Hydrochloride (tautomeric form); 851074-40-3
EINECS	Contact for details

Quality Control

Our o-Acetyl-n-tert-Butylhydroxylamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and process chemistry. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent performance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.