Description

tert-Butyl n-(1-Hydroxy-2,2,2-Trifluoroethyl)Carbamate is a high-value, protected amino alcohol derivative featuring a trifluoroethyl group. This compound is a critical chiral building block in advanced organic synthesis, prized for its ability to introduce fluorine-containing motifs and its orthogonal protecting group strategy. It is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, where its structural features can significantly influence the metabolic stability and bioavailability of target molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of fluorinated drug candidates, including protease inhibitors and CNS-active compounds.
• Agrochemical Synthesis: Used in the research and production of advanced, fluorinated pesticides and herbicides to enhance efficacy and environmental profile.
• Peptide Chemistry: Serves as a protected β-amino acid analog for the incorporation of fluorinated residues into peptide chains, modifying their physical and biological properties.
• Ligand and Catalyst Development: Employed as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Investigated as a monomer or building block for specialty polymers with unique surface properties due to the fluorine content.
• Chemical Biology Probes: Utilized in the design of molecular probes and tags for studying biological systems.

Basic Information

Product Name	tert-Butyl n-(1-Hydroxy-2,2,2-Trifluoroethyl)Carbamate
CAS No.	17049-74-0
Molecular Formula	C7H12F3NO3
Molecular Weight	215.17 g/mol
Synonyms	N-Boc-2-Amino-1,1,1-trifluoro-2-propanol; 1,1-Dimethylethyl N-(1-Hydroxy-2,2,2-trifluoroethyl)carbamate; 2-[(tert-Butoxycarbonyl)amino]-1,1,1-trifluoropropan-2-ol; (2-Hydroxy-1,1,1-trifluoropropan-2-yl)carbamic acid tert-butyl ester; BOC-Amino-TFE; tert-Butyl (1-hydroxy-2,2,2-trifluoroethyl)carbamate; N-(tert-Butoxycarbonyl)-2-amino-1,1,1-trifluoro-2-propanol
EINECS	Contact for details

Quality Control

Our tert-Butyl n-(1-Hydroxy-2,2,2-Trifluoroethyl)Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment, to ensure it meets the high standards required for research and scale-up applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to guarantee traceability and consistency for your critical synthesis work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect product stability and performance. Keep away from incompatible materials such as strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.