Description

Methyl 3-Fluoro-4-Hydroxy-5-Nitrobenzoate is a high-purity, multi-functional aromatic ester building block designed for advanced chemical synthesis. This compound is valued for its unique molecular architecture, which combines a reactive methyl ester, a phenolic hydroxyl group, a nitro substituent, and a fluorine atom, enabling precise modifications in complex molecule construction. It is primarily sought after by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, particularly those targeting specific enzyme pathways where the fluorine atom enhances metabolic stability and bioavailability.
• Agrochemical Research: Used in developing new herbicides, fungicides, and insecticides, where the nitro and hydroxy groups serve as handles for further functionalization.
• Liquid Crystal & OLED Material Synthesis: Serves as a building block for advanced organic electronic materials due to its planar aromatic structure and polar substituents.
• Dye & Pigment Intermediate: Employed in the production of specialized dyes and pigments, where the nitro group contributes to color properties.
• Cross-Coupling Reactions: The aromatic halide (fluorine) and ester functionalities make it a suitable substrate for palladium-catalyzed cross-coupling reactions like Suzuki or Buchwald-Hartwig amination.
• Academic & Contract Research: A valuable reagent for methodological studies in organic chemistry, exploring new fluorination techniques and ester transformations.

Basic Information

Product Name	Methyl 3-Fluoro-4-Hydroxy-5-Nitrobenzoate
CAS No.	850335-27-2
Molecular Formula	C8H6FNO5
Molecular Weight	215.14 g/mol
Synonyms	3-Fluoro-4-hydroxy-5-nitrobenzoic acid methyl ester; Methyl 3-fluoro-4-hydroxy-5-nitrobenzoate; Benzoic acid, 3-fluoro-4-hydroxy-5-nitro-, methyl ester; Methyl 3-fluoro-4-hydroxy-5-nitrobenzoate; 850335-27-2; MFCD28425328
EINECS	Contact for details

Quality Control

Every batch of Methyl 3-Fluoro-4-Hydroxy-5-Nitrobenzoate is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high standards required for research and commercial synthesis. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (by HPLC), identity (by IR and NMR), and impurity profiles. Our quality commitment supports compliance in cGMP and ISO 9001 environments where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.