Description

Ho-Peg5-Tbu is a high-purity, functionalized polyethylene glycol (PEG) derivative featuring a terminal hydroxyl group and a tert-butyl (tBu) protecting group. This compound is a critical intermediate for the synthesis of advanced bioconjugates and drug delivery systems, offering precise control over molecular architecture and solubility. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require reliable, well-defined PEG linkers for developing next-generation therapeutics and diagnostics.

Application

• Pharmaceutical Linker Chemistry: Serves as a versatile spacer or linker for the controlled conjugation of active pharmaceutical ingredients (APIs), peptides, or antibodies to enhance pharmacokinetics.
• Prodrug Synthesis: Used in the design and synthesis of prodrugs where the PEG chain modulates solubility and the tBu group allows for selective deprotection under mild conditions.
• Polymer Therapeutics: A key building block for creating complex, multi-arm PEG-based polymers used in drug delivery platforms like PEGylated nanoparticles and hydrogels.
• Bioconjugation Reagent: Facilitates the attachment of targeting ligands, dyes, or reporter molecules to biomolecules for diagnostic and therapeutic applications.
• Surface Modification: Employed to functionalize surfaces of medical devices or nanomaterials to improve biocompatibility and reduce non-specific binding.
• Chemical Biology Tool: Provides a handle for introducing PEG chains into small molecules or biomacromolecules to study their function and interaction in aqueous environments.

Basic Information

Product Name	Ho-Peg5-Tbu
CAS No.	850090-09-4
Molecular Formula	C24H48O11
Molecular Weight	512.64 g/mol
Synonyms	1-Amino-3,6,9,12,15-pentaoxaheptadecan-17-ol, 17-tert-butoxy; 17-(tert-Butoxy)-3,6,9,12,15-pentaoxaheptadecan-1-amine; HO-PEG5-t-butyl ether; 5-Amino-3-oxapentyl 2-[2-[2-[2-(2-tert-butoxyethoxy)ethoxy]ethoxy]ethoxy]ethyl ether; tert-Butyl-PEG5-alcohol; Amino-PEG5-t-butyl alcohol; PEG5-tBu-OH; Amino-terminated PEG t-butyl ether
EINECS	Contact for details

Quality Control

Every batch of Ho-Peg5-Tbu is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and MS analysis. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.