Description

2,4-Difluoropyridine-3-Carboxylic Acid is a high-value fluorinated pyridine derivative serving as a critical building block in advanced organic synthesis. This compound is essential for medicinal chemistry research and development, enabling the introduction of both fluorine atoms and a carboxylic acid functional group into target molecules. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers for creating novel active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in kinase inhibitor and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the difluoropyridine moiety enhances biological activity and metabolic stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of fluorinated organic electronic materials and liquid crystals.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.
• Academic & Industrial R&D: Utilized in exploratory chemistry to study structure-activity relationships (SAR) and develop new synthetic methodologies.

Basic Information

Product Name	2,4-Difluoropyridine-3-Carboxylic Acid
CAS No.	849937-90-2
Molecular Formula	C6H3F2NO2
Molecular Weight	159.09 g/mol
Synonyms	3-Pyridinecarboxylic acid, 2,4-difluoro-; 2,4-Difluoronicotinic Acid; 2,4-Difluoro-3-pyridinecarboxylic Acid; 2,4-Difluoro-3-carboxypyridine; Difluoropyridinecarboxylic Acid; 849937-90-2; Nicotinic acid, 2,4-difluoro-
EINECS	Contact for details

Quality Control

Our 2,4-Difluoropyridine-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications in GMP and ISO-compliant environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. Due to its chemical nature, the material should be handled in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.