Description

Benzo[B][1,6]Naphthyridine-10-Carbonitrile, 1,2,3,4-Tetrahydro-2-(1-Methylethyl)- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in drug discovery and process development for oncology, neurology, and antiviral applications.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates and novel chemical entities.
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis to develop new therapeutic agents.
• API Synthesis: Serves as a core scaffold for constructing final active pharmaceutical ingredients, especially those targeting kinase inhibition.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological pathways and target validation.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable synthetic routes from laboratory to pilot plant scale.
• Contract Research & Manufacturing (CRMO): Supplied to service organizations supporting pharmaceutical companies with custom synthesis and development.

Basic Information

Product Name	Benzo[B][1,6]Naphthyridine-10-Carbonitrile, 1,2,3,4-Tetrahydro-2-(1-Methylethyl)-
CAS No.	849587-90-2
Molecular Formula	C16H17N3
Molecular Weight	251.33 g/mol
Synonyms	2-Isopropyl-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridine-10-carbonitrile; 1,2,3,4-Tetrahydro-2-isopropylbenzo[b][1,6]naphthyridine-10-carbonitrile; 849587-90-2; Benzo[b][1,6]naphthyridine-10-carbonitrile, 1,2,3,4-tetrahydro-2-(1-methylethyl)-; Tetrahydro-2-isopropylbenzonaphthyridinecarbonitrile
EINECS	Contact for details

Quality Control

Every batch of Benzo[B][1,6]Naphthyridine-10-Carbonitrile, 1,2,3,4-Tetrahydro-2-(1-Methylethyl)- is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.