Description

(E)-n-(4-Chloro-3-Cyano-7-Ethoxyquinolin-6-Yl)-4-(Dimethylamino)But-2-Enamide is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is critical for research and development in medicinal chemistry, offering a precise building block for creating novel therapeutic agents. It is primarily utilized by pharmaceutical manufacturers, biotechnology firms, and contract research organizations (CROs) engaged in the development of targeted drug candidates.

Application

• Pharmaceutical Intermediate: Key synthetic precursor in the research and production of novel drug candidates, particularly in oncology and other specialized therapeutic areas.
• Medicinal Chemistry Research: Serves as a crucial scaffold for structure-activity relationship (SAR) studies and the optimization of lead compounds in drug discovery pipelines.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in multi-step synthetic routes for the manufacture of complex, high-value target molecules.
• Biochemical Research: Employed in the study of biological pathways and the development of enzyme inhibitors or receptor modulators.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP-compliant production of clinical trial materials and commercial APIs.

Basic Information

Product Name	(E)-n-(4-Chloro-3-Cyano-7-Ethoxyquinolin-6-Yl)-4-(Dimethylamino)But-2-Enamide
CAS No.	848133-88-0
Molecular Formula	C₁₈H₁₉ClN₄O₂
Molecular Weight	358.82 g/mol
Synonyms	(E)-N-(4-Chloro-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide; 4-Chloro-6-[[(2E)-4-(dimethylamino)-2-butenoyl]amino]-7-ethoxy-3-quinolinecarbonitrile; (2E)-N-(4-Chloro-3-cyano-7-ethoxy-6-quinolyl)-4-(dimethylamino)but-2-enamide; 848133-88-0; But-2-enamide, N-(4-chloro-3-cyano-7-ethoxy-6-quinolinyl)-4-(dimethylamino)-, (2E)-; (E)-4-(Dimethylamino)-N-(4-chloro-3-cyano-7-ethoxyquinolin-6-yl)but-2-enamide
EINECS	Contact for details

Quality Control

Our (E)-n-(4-Chloro-3-Cyano-7-Ethoxyquinolin-6-Yl)-4-(Dimethylamino)But-2-Enamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.