Description

5-Nitro-2-(Trifluoromethyl)Benzoic Acid is a high-purity, multifunctional aromatic building block characterized by its nitro and trifluoromethyl substituents. This compound is valued for its role as a critical intermediate in the synthesis of advanced pharmaceutical agents and agrochemicals, where its unique electronic properties can modulate bioactivity and metabolic stability. It is primarily sought after by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and biological activity.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of advanced polymers, liquid crystals, and organic electronic materials.
• Dye & Pigment Industry: Acts as an intermediate for synthesizing specialized azo dyes and pigments that require nitro and carboxylic acid functionalities.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, amide bond formation, and nucleophilic aromatic substitution to introduce functional complexity.
• Chemical Research & Development: Utilized in academic and industrial labs for method development, catalysis studies, and exploring new chemical spaces in medicinal chemistry.

Basic Information

Product Name	5-Nitro-2-(Trifluoromethyl)Benzoic Acid
CAS No.	847547-06-2
Molecular Formula	C8H4F3NO4
Molecular Weight	235.12 g/mol
Synonyms	2-(Trifluoromethyl)-5-nitrobenzoic acid; 5-Nitro-α,α,α-trifluoro-o-toluic acid; Benzoic acid, 5-nitro-2-(trifluoromethyl)-; 5-Nitro-2-trifluoromethylbenzoic acid; 5-Nitro-α,α,α-trifluoro-2-methylbenzoic acid; 2-Trifluoromethyl-5-nitrobenzoic acid; 847547-06-2
EINECS	Contact for details

Quality Control

Our 5-Nitro-2-(Trifluoromethyl)Benzoic Acid is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring GMP-grade intermediates and research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly closed to prevent contamination and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.