Description

(S)-1-(3,4-Difluorophenyl)Propan-1-Amine Hydrochloride CAS NO 847448-46-8 is a high-purity chiral amine hydrochloride salt, serving as a critical pharmaceutical intermediate and building block in advanced organic synthesis. Its value lies in providing a stereochemically defined, fluorinated aromatic scaffold essential for developing novel active pharmaceutical ingredients (APIs) with enhanced metabolic stability and binding affinity. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the development and scale-up of fluorinated APIs, leveraging the properties of the difluorophenyl group.
• Agrochemical Research: Serves as a precursor in the design of new herbicides, fungicides, and insecticides with improved efficacy.
• Ligand and Catalyst Development: Employed in the creation of chiral ligands for asymmetric catalysis and metal complexes.
• Chemical Biology & Proteomics: Utilized as a molecular probe or tag in biochemical research due to its specific structural features.
• Material Science: A potential monomer or additive for creating specialty polymers with unique optical or electronic properties.

Basic Information

Product Name	(S)-1-(3,4-Difluorophenyl)Propan-1-Amine Hydrochloride
CAS No.	847448-46-8
Molecular Formula	C9H10F2N•HCl
Molecular Weight	205.64 (Free base) / 242.10 (HCl salt)
Synonyms	(S)-1-(3,4-Difluorophenyl)propylamine hydrochloride; (S)-3,4-Difluoro-α-methylbenzenemethanamine hydrochloride; (S)-1-Amino-1-(3,4-difluorophenyl)propane hydrochloride; (S)-α-Methyl-3,4-difluorobenzylamine hydrochloride; (S)-3',4'-Difluoropropiophenone imine hydrochloride (reduction precursor); (S)-1-(3,4-Difluorophenyl)-1-aminopropane HCl; (S)-DFPA•HCl
EINECS	Contact for details

Quality Control

Our production of (S)-1-(3,4-Difluorophenyl)Propan-1-Amine Hydrochloride adheres to stringent quality protocols suitable for pharmaceutical intermediate applications. Every batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure high chemical and enantiomeric purity. Certificates of Analysis (COA) detailing identity, assay, impurity profile, and residual solvents are provided and available upon request. Our quality management system supports compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.