Description

(S)-α-Amino-3-Quinolinepropanoic Acid Methyl Ester Dihydrochloride is a high-purity, non-natural amino acid derivative of significant interest in advanced pharmaceutical research and development. This chiral building block is crucial for the synthesis of complex molecules, particularly in the creation of novel therapeutic agents and bioactive compounds. It is primarily utilized by research institutions, pharmaceutical companies, and fine chemical manufacturers engaged in drug discovery, peptide chemistry, and the development of enzyme inhibitors.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of potential drug candidates, especially those targeting neurological and oncological pathways.
• Peptide Mimetic Research: Used to incorporate quinoline-based structures into peptide backbones to modulate bioavailability, stability, and receptor binding affinity.
• Protease & Enzyme Inhibitor Development: Serves as a core component in designing inhibitors for various enzymes due to its specific stereochemistry and functional groups.
• Chemical Biology & Probe Synthesis: Employed in the creation of molecular probes for studying biological processes and protein interactions.
• Asymmetric Synthesis: Utilized as a starting material or auxiliary in stereoselective chemical reactions to construct complex chiral centers.
• Academic & Industrial R&D: Fundamental research reagent for exploring new chemical entities and reaction methodologies in organic and medicinal chemistry.

Basic Information

Product Name	(S)-α-Amino-3-Quinolinepropanoic Acid Methyl Ester Dihydrochloride
CAS No.	845907-94-0
Molecular Formula	C₁₃H₁₄N₂O₂ • 2HCl
Molecular Weight	311.18 g/mol (Free base: 230.26 g/mol)
Synonyms	(S)-2-Amino-3-(quinolin-3-yl)propanoic acid methyl ester dihydrochloride; Methyl (S)-2-amino-3-(3-quinolyl)propionate dihydrochloride; (S)-3-Quinolinealanine methyl ester dihydrochloride; L-3-(3-Quinolyl)alanine methyl ester hydrochloride; (S)-α-Amino-3-quinolinepropionic acid methyl ester HCl; (S)-3-Qal-OMe • 2HCl; (S)-3-Quinolin-3-yl-alanine methyl ester dihydrochloride
EINECS	Contact for details

Quality Control

Our (S)-α-Amino-3-Quinolinepropanoic Acid Methyl Ester Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and development applications. A Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral excess, and other critical parameters is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.