Description

1-(4-Bromobenzyloxy)-2,5-Difluorobenzene is a high-purity, multi-functional aromatic ether building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both bromo and fluoro substituents, makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced bioactivity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a building block for advanced electronic materials, including liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs), due to its aromatic core and halogen substituents.
• Polymer & Resin Modifier: Employed to introduce halogenated aromatic units into polymer chains, modifying properties such as flame retardancy, thermal stability, and refractive index.
• Cross-Coupling Reactions: The bromobenzyl moiety acts as an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to create complex biaryl and conjugated systems.
• Chemical Research & Development: A valuable reagent for academic and industrial research in medicinal chemistry, materials science, and methodology development.

Basic Information

Product Name	1-(4-Bromobenzyloxy)-2,5-Difluorobenzene
CAS No.	845866-76-4
Molecular Formula	C₁₃H₉BrF₂O
Molecular Weight	299.11 g/mol
Synonyms	2,5-Difluoro-1-[(4-bromophenyl)methoxy]benzene; 1-[(4-Bromobenzyl)oxy]-2,5-difluorobenzene; 4-Bromobenzyl 2,5-Difluorophenyl Ether; Benzene, 1-(4-bromobenzyloxy)-2,5-difluoro-; (4-Bromobenzyloxy)-2,5-difluorobenzene
EINECS	Contact for details

Quality Control

Our 1-(4-Bromobenzyloxy)-2,5-Difluorobenzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and relevant industry standards for research and process chemistry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.