Description

(1S,4S)-(+)-2-Naphthalen-2-Ylmethyl-2,5-Diaza-Bicyclo[2.2.1]Heptane 2Cf3Cooh is a high-purity, chiral bicyclic diamine derivative, specifically designed as a sophisticated building block and ligand for advanced chemical synthesis. Its value lies in its rigid, three-dimensional structure and the presence of a naphthylmethyl group, which makes it an essential intermediate for creating novel compounds with specific stereochemical and electronic properties. This product is primarily needed by research and development teams in the pharmaceutical and agrochemical sectors, where it serves as a key precursor for drug discovery programs, catalyst development, and the synthesis of complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research.
• Asymmetric Catalyst Ligand: Used to develop and screen new chiral ligands for transition metal catalysis, enabling enantioselective synthesis in fine chemical production.
• Agrochemical Research: Serves as a precursor in the development of new herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science: Employed in the synthesis of specialty polymers and advanced organic materials that require specific molecular recognition or chiral dopants.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) conducting fundamental research in organic chemistry and medicinal chemistry.
• Process Chemistry Development: Used to optimize scalable synthetic routes for complex molecules in pilot plant and manufacturing settings.

Basic Information

Product Name	(1S,4S)-(+)-2-Naphthalen-2-Ylmethyl-2,5-Diaza-Bicyclo[2.2.1]Heptane 2Cf3Cooh
CAS No.	845866-75-3
Molecular Formula	C₂₀H₂₁F₃N₂O₂
Molecular Weight	378.39 g/mol
Synonyms	(1S,4S)-2-[(Naphthalen-2-yl)methyl]-2,5-diazabicyclo[2.2.1]heptane trifluoroacetate; (1S,4S)-(+)-2-(2-Naphthylmethyl)-2,5-diazabicyclo[2.2.1]heptane TFA salt; 2,5-Diaza-bicyclo[2.2.1]heptane, 2-(2-naphthalenylmethyl)-, (1S,4S)-, 2,2,2-trifluoroacetate (1:1); (1S,4S)-2-(Naphthalen-2-ylmethyl)-2,5-diazabicyclo[2.2.1]heptane trifluoroacetic acid salt; (1S,4S)-N-[(2-Naphthyl)methyl]-2,5-diazabicyclo[2.2.1]heptane TFA; Chiral Bicyclic Diamine TFA Salt; 845866-75-3
EINECS	Contact for details

Quality Control

Our (1S,4S)-(+)-2-Naphthalen-2-Ylmethyl-2,5-Diaza-Bicyclo[2.2.1]Heptane 2Cf3Cooh is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the exacting standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and other critical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.