Description

2-Bromo-5-Cyanobenzoic Acid is a versatile aromatic building block characterized by its bromine and cyano functional groups, which serve as key handles for further synthetic elaboration. This compound is essential for the development of advanced pharmaceutical intermediates and functional materials, offering a critical balance of reactivity and stability for complex organic synthesis. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides and fungicides, where the bromine atom allows for efficient cross-coupling reactions.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science: Employed in the synthesis of organic semiconductors, liquid crystals, and polymers requiring specific electronic properties.
• Chemical Research: A valuable reagent in academic and industrial R&D for exploring new reaction pathways and constructing complex molecular architectures.
• Dye and Pigment Intermediate: Acts as a building block for advanced colorants and functional dyes.

Basic Information

Product Name	2-Bromo-5-Cyanobenzoic Acid
CAS No.	845616-12-8
Molecular Formula	C8H4BrNO2
Molecular Weight	226.03 g/mol
Synonyms	5-Cyano-2-bromobenzoic Acid; Benzoic acid, 2-bromo-5-cyano-; 2-Bromo-5-cyanobenzoic acid; 845616-12-8; 2-Brom-5-cyanbenzoesäure (German); Acide 2-bromo-5-cyanobenzoïque (French); Ácido 2-bromo-5-cianobenzoico (Spanish)
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-Cyanobenzoic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.