Description

5-Azaspiro[2.5]Octane-6,8-Dione is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic structure. This compound is of significant value in medicinal chemistry for its role as a versatile building block in the synthesis of complex, bioactive molecules. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly within the fields of oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates.
• Medicinal Chemistry Research: Used as a constrained scaffold to explore structure-activity relationships (SAR) and improve drug-like properties such as metabolic stability and selectivity.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or component in the design of bifunctional molecules for targeted protein degradation.
• Chemical Biology Probes: Utilized in the creation of tool compounds for studying biological pathways and target validation.
• Organic Synthesis: Acts as a specialized building block for constructing complex heterocyclic and spirocyclic frameworks in academic and industrial R&D.

Basic Information

Product Name	5-Azaspiro[2.5]Octane-6,8-Dione
CAS No.	845267-72-3
Molecular Formula	C7H9NO2
Molecular Weight	139.15 g/mol
Synonyms	6,8-Dioxo-5-azaspiro[2.5]octane; 5-Azaspiro[2.5]octane-6,8-dione; 1-Azaspiro[2.5]octane-2,4-dione (tautomeric form); Spiro[2.5]octane-6,8-dione, 5-aza-; 5-Aza-spiro[2.5]octane-6,8-dione
EINECS	Contact for details

Quality Control

Our 5-Azaspiro[2.5]Octane-6,8-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability, consistency, and reliability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product should be kept under an inert atmosphere if long-term storage is required to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.