Description

1-(3-Bromo-Phenyl)-2,2,2-Trifluoro-Ethylamine Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its bromo-phenyl and trifluoroethylamine hydrochloride structure. This compound is essential for medicinal chemistry research and development, serving as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate halogenated and fluorinated motifs into target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in CNS and oncology therapeutic areas.
• Medicinal Chemistry Building Block: Used to introduce both bromine and trifluoromethyl groups into molecular scaffolds, enabling structure-activity relationship (SAR) studies.
• Agrochemical Synthesis: Serves as a precursor in the development of advanced pesticides and herbicides that require halogenated aromatic components.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds and probes for biochemical and pharmacological research.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes under cGMP conditions.
• Fluorine Chemistry Research: Valuable for academic and industrial research focused on the properties and applications of organofluorine compounds.

Basic Information

Product Name	1-(3-Bromo-Phenyl)-2,2,2-Trifluoro-Ethylamine Hydrochloride
CAS No.	842169-71-5
Molecular Formula	C8H8BrClF3N
Molecular Weight	290.51 g/mol
Synonyms	1-(3-Bromophenyl)-2,2,2-trifluoroethanamine hydrochloride; 3-Bromo-α,α,α-trifluoroethylbenzylamine hydrochloride; 1-(3-Bromophenyl)-2,2,2-trifluoroethylamine HCl; 3-Bromo-α-(trifluoromethyl)benzylamine hydrochloride; (3-Bromophenyl)(trifluoromethyl)methylamine hydrochloride; 1-(3-Bromophenyl)-2,2,2-trifluoroethan-1-amine hydrochloride; α-(3-Bromophenyl)-α-(trifluoromethyl)methylamine hydrochloride
EINECS	Contact for details

Quality Control

Our 1-(3-Bromo-Phenyl)-2,2,2-Trifluoro-Ethylamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our quality commitment aligns with ICH guidelines, and we support development under cGMP standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.