Description

3-(1,3-Dioxolan-2-Ylmethyl)-1-Fluorobenzene is a specialized fluorinated aromatic building block featuring a protected aldehyde functionality. This compound matters for its role as a versatile intermediate in the synthesis of complex molecules, particularly in pharmaceutical and agrochemical research. It is needed by R&D chemists and process development scientists working on active ingredients, fine chemicals, and advanced material precursors where precise fluorine substitution and controlled functional group manipulation are critical.

Application

• Pharmaceutical Intermediate: Key synthon for the development of fluorinated drug candidates, including potential CNS-active molecules and enzyme inhibitors.
• Agrochemical Synthesis: Used in constructing advanced herbicides, fungicides, and pesticides where the fluorine atom enhances biological activity and environmental stability.
• Liquid Crystal & OLED Material Research: Serves as a precursor for fluorinated aromatic cores in electronic and display materials.
• Fine Chemical Production: Employed in custom synthesis and contract manufacturing for specialty fluoroorganic compounds.
• Academic & Industrial R&D: A valuable reagent for methodology development in organic synthesis, particularly in cross-coupling and functional group transformation reactions.

Basic Information

Product Name	3-(1,3-Dioxolan-2-Ylmethyl)-1-Fluorobenzene
CAS No.	842123-99-3
Molecular Formula	C10H11FO2
Molecular Weight	182.19 g/mol
Synonyms	1-Fluoro-3-(1,3-dioxolan-2-ylmethyl)benzene; 2-[(3-Fluorophenyl)methyl]-1,3-dioxolane; 3-Fluorobenzaldehyde ethylene acetal; (3-Fluorobenzylidene)acetaldehyde cyclic acetal; 3-Fluorobenzaldehyde cyclic ethylene acetal; 2-((3-Fluorobenzyl)oxy)-1,3-dioxolane (incorrect but common search variant); Benzene, 1-fluoro-3-[(1,3-dioxolan-2-yl)methyl]-
EINECS	Contact for details

Quality Control

Our 3-(1,3-Dioxolan-2-Ylmethyl)-1-Fluorobenzene is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality system supports development and cGMP manufacturing requirements for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.